Table 4 Studies evaluating the effectiveness of CBT-E for adolescents

Dalle Grave [17]

2013

Case series

n = 46;

n = 29 completers

Mean = 15.5 years (SD = 1.3, range 13–17 years)

Mean = 2.86 (SD = 3.35)

Yes, 60 weeks (n = 29)

Mean BMI-for-age percentile 30.3 (SD = 16.7)

96.6% of completers

had minimal residual eating-disorder psychopathology^a

Mean BMI-for-age percentile 35.1 (SD = 26.0)

89.7% of completers

had minimal residual eating-disorder psychopathology^a

Dalle Grave [18]

2015

Case series

n = 68; n = 51 completers

Mean = 16.5 years (SD = 1.7; range 13–19 years)

Mean = 42.9 (SD = 23.2)

No

Forty-six patients (67.6%) had minimal residual eating disorder psychopathology. The frequency of binge eating, self- induced vomiting and laxative misuse decreased substantially

–-

Calugi [13]

2015

Case series

Adolescent:

N = 46;

n = 29 completers

Adults:

n = 49;

n = 32 completers

Adolescents: Mean = 15.5 (SD = 1.3)

Adults: Mean BMI = 24.6 (SD = 5.2)

Adolescents: Mean = 2.86 (SD = 3.35)

Adults:

Mean BMI = 17.7 (SD = 1.4)

No

Adolescents: 65.3% had reached a BMI-for-age percentile corresponding to BMI ≥ 18.5 in adults

Adults: 36.5% reached a BMI ≥ 18.5

–-

Dalle Grave [19]

2019

Case series

n = 49;

n = 35 completers

Mean = 15.5 years

(SD = 1.7, range 11–18 years)

Mean = 5.67 (SD = 7.30)

Yes, 20 weeks (n = 29)

Mean BMI-for-age percentile 32.3 (SD = 4.6) ITT analysis

Significant improvement of eating-disorder and general psychopathology

Mean BMI-for-age percentile 30.5 (SD = 2.6) ITT analysis

Significant improvement of eating-disorder and general psychopathology

Dalle Grave [20]

2020

Case series

Adolescent:

N = 74;

n = 63 completers

Adults:

n = 81;

n = 71 completers

Adolescents: Mean = 16.5 (SD = 1.4, range 13–19 years)

Adults: Mean BMI = 30.6 (SD = 11.6, range 20–58 years)

Adolescents: Mean = 1.4 (SD = 3.2)

Adults:

Mean BMI = 15.1 (SD = 2.3)

Yes, 20 and 60 weeks

Adolescents: n = 46 at 20-week and n = 45 at 60-week follow-up

Adults: n = 53 at 20-week and n = 36 at 60-week follow-up

Adolescents: mean BMI-for-age percentile 32.1 (SE = 2.0)

Adults: mean BMI 19.9 (SE = 0.1)

ITT analysis

Significant improvement of eating-disorder and general psychopathology for both groups

Adolescents: mean BMI-for-age percentile 31.3 (SE = 2.9) at 20-week and 23.2 (SE = 4.4) at 60-week follow-up

Adults: mean BMI 19.7 (SE = 0.2) at 20-week and 18.6 (SE = 0.3) at 60-week follow-up

Significant improvement of eating-disorder and general psychopathology for both groups

Le Grange [21]

2020

Non-randomized

effectiveness trial

CBT-E: n = 46;

n = 29 completers

FBT: n = 51; n = 33 completers

Mean = 14.6 years

(SD = 1.8, range 11–19)

CBT-E lower weight:

% median BMI = 3.50

CBT-E higher weight: % median BMI = 11.72

FBT lower weight:

% median BMI = 3.97

FBT higher weight: % median BMI = 12.09

Yes, 6 and 12 months

6 months: CBT-E n = 22; FBT n = 20

12 months: CBT-E n = 16; FBT n = 23

CBT-E lower weight: % median BMI = 94.4 Significant improvement in eating-disorder and general psychopathology

CBT-E higher weight: % median BMI = 108.3

Significant improvement in eating-disorder and general psychopathology

FBT lower weight: % median BMI = 96.8 Significant improvement in eating-disorder and general psychopathology

FBT higher weight: % median BMI = 112.6 Significant improvement in eating-disorder and general psychopathology

CBT-E lower weight: % median BMI = 96.4 Significant improvement in eating-disorder and general psychopathology

CBT-E higher weight: % median BMI = 107.2 Significant improvement in eating-disorder and general psychopathology

FBT lower weight: % median BMI = 96.2 Significant improvement in eating-disorder and general psychopathology

FBT higher weight: % median BMI = 111.5 Significant improvement in eating-disorder and general psychopathology

Dalle Grave [22]

2023

Case series

Adolescents: n = 61

n = 44 completers

Young adults:

n = 54 (18–25 years)

n = 28 completers

Mean = 17 years (SD = 2.8, range 14–25)

Adolescents:

Mean = 5.5 (SD = 6.3)

Young adults:

Mean BMI = 16.1 (SD = 1.4)

Adolescents:

Mean BMI-for-age percentile 29.4 (SE = 3.6) ITT analysis

Significant improvement of eating-disorder and general psychopathology

Young adults:

Mean BMI 19.3 (SE = 0.8)

Significant improvement of eating-disorder and general psychopathology

Adolescents:

Mean BMI-for-age percentile 30.0 (SE = 3.9) ITT analysis

Significant improvement of eating-disorder and general psychopathology

Young adults:

Mean BMI 19.6 (SE = 1.3)

Significant improvement of eating-disorder and general psychopathology