Corticotropin-releasing hormone receptor-1 antagonist attenuates visceral hypersensitivity induced by trinitrobenzene sulfonic acid colitis and maternal separation in rats

Table 1 Anxiety-related behavior of experimental rats

	%Time Spent in Open Arms	Number of Entries into Open Arms
	Mean ± SE	Mean ± SE
control	14.6 ± 5.4	2.0 ± 0.8
TNBS	15.3 ± 7.4	2.1 ± 0.8
MS	23.6 ± 6.9	2.4 ± 0.6
MS + TNBS	20.7 ± 7.0	3.6 ± 1.1
MS + TNBS + CP	34.6 ± 6.7	4.6 ± 0.8

No significant difference in the percentage of time spent in the open arms or the number of entries into the open arms by the elevated plus maze was found among controls (n = 9), TNBS (n = 7), MS (n = 9), MS + TNBS (n = 7), and MS + TNBS + CP (n = 7) rats

ISSN: 1751-0759